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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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16 – 30 of 582 results
16

Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Solid
Molecular Weight (g/mol) 425.39
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 17.6 Å
Product Line Pierce
PEGylated Yes
17

Thermo Scientific™ BS(PEG)9

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

EDGE
18

Thermo Scientific™ EGS (ethylene glycol bis(succinimidyl succinate))
GSA_VA

Crosslink amines to amines with this membrane permeable crosslinker composed of NHS-ester groups and a 16.1A hydroxylamine-cleavable spacer arm.

EDGE
19

Thermo Scientific™ SPB (succinimidyl-[4-(psoralen-8-yloxy)]-butyrate)

Crosslink amines to DNA with this crosslinker composed of NHS-ester and psoralen reactive groups; conjugates to DNA via light-activated intercalation next to pyrimidine bases.

EDGE
20

Thermo Scientific™ EMCS (N-ε-malemidocaproyl-oxysuccinimide ester)
GSA_VA

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 8-atom (9.4A) spacer arm.

EDGE
21

Thermo Scientific™ SM(PEG)12 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Liquid
Molecular Weight (g/mol) 865.92
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Long (>30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 53.4 Å
Product Line Pierce
PEGylated Yes
22

Thermo Scientific™ Pierce™ Sulfo-SANPAH, No-Weigh™ Format

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store at -20°C protected from light and moisture.
Cleavable By Thiols
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 492.4
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Nonselective
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Spacer Arm Length 18.2 Å
PEGylated No
23

Thermo Scientific™ PMPI (p-maleimidophenyl isocyanate)

Short (8.7A) hydroxyl-to-sulfhydryl crosslinker; isocyanate and maleimide groups; label -OH by urethane bonds for conjugation to cysteines by thioether bonds.

EDGE
24

Thermo Scientific™ BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

EDGE
Content And Storage Upon receipt store desiccated at -20°C.
Description BS(PEG)5
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 532.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 21.7 Å
PEGylated Yes
25

Thermo Scientific™ AMAS (N-α-maleimidoacet-oxysuccinimide ester)

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 4-atom (4.4A) spacer arm.

EDGE
26

Thermo Scientific™ Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of a water-soluble, 8-atom (9.4A) spacer arm.

EDGE
27

Thermo Scientific™ SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))

Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 12-atom (14.2A) spacer arm.

EDGE
28

Thermo Scientific™ SM(PEG)4 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Solid
Molecular Weight (g/mol) 513.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 24.6 Å
Product Line Pierce
PEGylated Yes
29

Thermo Scientific Pierce™ Pierce™ SM(PEG)2, No-Weigh™ Format

Thermo Scientific™ Pierce™ SM(PEG)2 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.

EDGE
30

Thermo Scientific™ DTME (dithiobismaleimidoethane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, cleavable crosslinker composed of maleimide groups and 11-atom (13.3A) disulfide spacer arm.

EDGE